{"product_id":"foxo4-dri","title":"FOXO4-DRI","description":"\u003ch2\u003eFOXO4-DRI\u003c\/h2\u003e\n\u003cp\u003eFOXO4-DRI is a research-grade D-amino acid retro-inverso peptide designed for preclinical investigation of cellular senescence, apoptosis, and tissue rejuvenation. Developed by Peter de Keizer and colleagues, FOXO4-DRI is a modified peptide that disrupts the interaction between the FOXO4 transcription factor and p53 in senescent cells, selectively triggering apoptosis in cells that have entered a state of permanent cell cycle arrest. It represents a significant tool compound in the emerging field of senolytic research.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eIn senescent cells, FOXO4 forms a complex with p53 that sequesters p53 in the nucleus and prevents apoptosis, allowing senescent cells to persist and secrete pro-inflammatory factors (the senescence-associated secretory phenotype, SASP). FOXO4-DRI competitively disrupts this FOXO4–p53 interaction, freeing p53 to translocate to the mitochondria and initiate the intrinsic apoptotic cascade selectively in senescent cells. Non-senescent cells, which do not rely on this FOXO4–p53 interaction for survival, are largely unaffected, conferring a degree of selectivity that makes FOXO4-DRI a valuable senolytic research tool.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCellular senescence and senolytic activity studies\u003c\/li\u003e\n\u003cli\u003eFOXO4–p53 protein–protein interaction research\u003c\/li\u003e\n\u003cli\u003eSASP modulation and tissue inflammation investigation\u003c\/li\u003e\n\u003cli\u003eAge-related tissue dysfunction and rejuvenation modelling\u003c\/li\u003e\n\u003cli\u003eApoptosis pathway selectivity in senescent vs. healthy cells\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₂₂₈H₃₈₈N₈₆O₆₄\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e2460055-10-9\u003c\/li\u003e\n\u003cli\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cspan class=\"T286Pc\" data-sfc-cp=\"\" data-sfc-root=\"ep\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003e\u003cstrong class=\"Yjhzub\" data-sfc-root=\"ep\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 700; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003eMolecular Weight:\u003c!--TgQPHd||[]--\u003e\u003c\/strong\u003e 5358.15 g\/mol\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"10mg","offer_id":58103427399944,"sku":"FOXO4-10MG","price":69.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/foxo4-dri.png?v=1782938602","url":"https:\/\/vantalabsuk.com\/products\/foxo4-dri","provider":"Vanta Labs","version":"1.0","type":"link"}