{"product_id":"cjc-1295-with-dac","title":"CJC-1295 (With DAC)","description":"\u003ch2\u003eCJC-1295 (With DAC)\u003c\/h2\u003e\n\u003cp\u003eCJC-1295 (With DAC) is a long-acting synthetic analogue of growth hormone-releasing hormone (GHRH), engineered with a Drug Affinity Complex (DAC) technology that enables covalent binding to serum albumin. This albumin conjugation dramatically extends the peptide's half-life to approximately 6–8 days, enabling sustained, non-pulsatile elevation of growth hormone levels in research models. It is used in preclinical studies investigating chronic GH\/IGF-1 axis stimulation and its downstream metabolic and anabolic effects.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eCJC-1295 (With DAC) binds to the GHRH receptor on pituitary somatotrophs, stimulating GH synthesis and secretion. The DAC moiety — a maleimidopropionic acid linker — reacts with the free thiol group of Cys34 on serum albumin, forming a stable covalent bond that protects the peptide from enzymatic degradation and renal clearance. This results in a prolonged GH release profile distinct from the pulsatile pattern of the No DAC variant, making it a useful tool for studying the differential effects of tonic versus pulsatile GH secretion.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eChronic GH\/IGF-1 axis stimulation and sustained anabolic signalling studies\u003c\/li\u003e\n\u003cli\u003eAlbumin-binding drug delivery and pharmacokinetic research\u003c\/li\u003e\n\u003cli\u003ePulsatile vs. tonic GH secretion comparison modelling\u003c\/li\u003e\n\u003cli\u003eBody composition, lipolysis, and metabolic regulation investigation\u003c\/li\u003e\n\u003cli\u003eGHRH receptor pharmacology and long-acting peptide studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₆₅H₂₆₉N₄₇O₄₆\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 863288-34-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3647.3 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103427039496,"sku":"CJC-DAC-2MG","price":20.9,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103427072264,"sku":"CJC-DAC-5MG","price":34.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/CJC-1295_With_DAC.png?v=1783026340","url":"https:\/\/vantalabsuk.com\/products\/cjc-1295-with-dac","provider":"Vanta Labs","version":"1.0","type":"link"}