{"product_id":"cjc-1295-no-dac","title":"CJC-1295 (No DAC)","description":"\u003ch2\u003eCJC-1295 (No DAC)\u003c\/h2\u003e\n\u003cp\u003eCJC-1295 (No DAC) is a synthetic analogue of growth hormone-releasing hormone (GHRH), engineered for enhanced stability and receptor affinity compared to the native peptide. Unlike the DAC (Drug Affinity Complex) variant, CJC-1295 without DAC has a shorter half-life, producing pulsatile growth hormone release that more closely mimics endogenous GH secretion patterns. It is widely used in preclinical research investigating the GH\/IGF-1 axis, pituitary function, and anabolic signalling.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eCJC-1295 (No DAC) binds to and activates the GHRH receptor (GHRHR) on pituitary somatotroph cells, stimulating the synthesis and pulsatile release of growth hormone. This in turn drives hepatic IGF-1 production, which mediates downstream anabolic and metabolic effects including protein synthesis, lipolysis, and cellular proliferation. The peptide incorporates amino acid substitutions that confer resistance to dipeptidyl peptidase IV (DPP-IV) cleavage, extending its activity relative to native GHRH(1-29).\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGH\/IGF-1 axis and pituitary somatotroph function studies\u003c\/li\u003e\n\u003cli\u003ePulsatile growth hormone secretion modelling\u003c\/li\u003e\n\u003cli\u003eAnabolic signalling and protein synthesis research\u003c\/li\u003e\n\u003cli\u003eBody composition and metabolic regulation investigation\u003c\/li\u003e\n\u003cli\u003eGHRH receptor pharmacology studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₅₂H₂₅₂N₄₄O₄₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 863288-34-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3367.9 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103426875656,"sku":"CJC-NODAC-2MG","price":12.95,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103426908424,"sku":"CJC-NODAC-5MG","price":25.95,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103426941192,"sku":"CJC-NODAC-10MG","price":34.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/CJC-1295_No_DAC.png?v=1783026503","url":"https:\/\/vantalabsuk.com\/products\/cjc-1295-no-dac","provider":"Vanta Labs","version":"1.0","type":"link"}