{"product_id":"ara-290","title":"ARA 290.00","description":"\u003ch2\u003eARA-290\u003c\/h2\u003e\n\u003cp\u003eARA-290 is a synthetic 11-amino acid peptide derived from the helix B surface of erythropoietin (EPO), specifically engineered to activate the innate repair receptor (IRR) — a heterodimer of the EPO receptor and the β common receptor (βcR) — without stimulating erythropoiesis or haematopoietic effects. It has been investigated in preclinical and early clinical research for its cytoprotective, anti-inflammatory, and neuroprotective properties.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eARA-290 selectively binds to the innate repair receptor (IRR), which is expressed on non-haematopoietic tissues including neurons, pancreatic β-cells, and immune cells. Activation of the IRR triggers anti-apoptotic and anti-inflammatory signalling cascades, including PI3K\/Akt and JAK2\/STAT3 pathways, promoting cell survival and tissue repair. Unlike full-length EPO, ARA-290 does not bind the classical homodimeric EPO receptor responsible for red blood cell production, making it a selective research tool for studying tissue protection independent of erythropoietic activity.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eInnate repair receptor (IRR) biology and signalling studies\u003c\/li\u003e\n\u003cli\u003eNeuroprotection and peripheral neuropathy research\u003c\/li\u003e\n\u003cli\u003ePancreatic β-cell survival and diabetes modelling\u003c\/li\u003e\n\u003cli\u003eAnti-inflammatory and cytoprotective research\u003c\/li\u003e\n\u003cli\u003eEPO-derived peptide pharmacology studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₅₁H₈₄N₁₆O₂₁\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1273.3 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1208243-50-8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"10mg","offer_id":58103426384136,"sku":"ARA290-10MG","price":24.9,"currency_code":"GBP","in_stock":true},{"title":"16mg","offer_id":58103426416904,"sku":"ARA290-16MG","price":37.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/ara-290.png?v=1782823826","url":"https:\/\/vantalabsuk.com\/products\/ara-290","provider":"Vanta Labs","version":"1.0","type":"link"}