{"product_id":"aicar","title":"AICAR","description":"\u003ch2\u003eAICAR\u003c\/h2\u003e\n\u003cp\u003eAICAR (5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, also known as Acadesine) is a nucleotide analogue and potent activator of AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. It is not a peptide but a small-molecule ribonucleoside that is phosphorylated intracellularly to its active monophosphate form (ZMP), which mimics AMP and activates AMPK. AICAR has been extensively studied in preclinical research for its roles in metabolic regulation, endurance performance, and cellular energy sensing.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eUpon cellular uptake, AICAR is phosphorylated by adenosine kinase to form ZMP (AICA ribonucleotide monophosphate), which accumulates intracellularly and allosterically activates AMPK by mimicking a high AMP:ATP ratio. AMPK activation triggers a cascade of metabolic adaptations including increased fatty acid oxidation, enhanced glucose uptake, mitochondrial biogenesis, and inhibition of anabolic pathways. This makes AICAR a valuable tool for studying metabolic disease, exercise physiology, and energy sensing pathways in vitro.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAMPK activation and energy sensing studies\u003c\/li\u003e\n\u003cli\u003eMetabolic syndrome and insulin resistance research\u003c\/li\u003e\n\u003cli\u003eMitochondrial biogenesis and fatty acid oxidation modelling\u003c\/li\u003e\n\u003cli\u003eExercise physiology and endurance research\u003c\/li\u003e\n\u003cli\u003eCardiac protection and ischaemia studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₉H₁₅N₄O₈P\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 338.21 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 2627-69-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"50mg","offer_id":58103426253064,"sku":"AICAR-50MG","price":30.99,"currency_code":"GBP","in_stock":true},{"title":"100mg","offer_id":58103426285832,"sku":"AICAR-100MG","price":60.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/aicar.png?v=1782823499","url":"https:\/\/vantalabsuk.com\/products\/aicar","provider":"Vanta Labs","version":"1.0","type":"link"}