{"product_id":"adipotide-fttp","title":"Adipotide \/ FTTP","description":"\u003ch2\u003eAdipotide \/ FTTP\u003c\/h2\u003e\n\u003cp\u003eAdipotide (also known as FTTP — Fatty acid-Targeted Proapoptotic Peptide — and PROHIBIT) is a proapoptotic research peptide designed to selectively target and destroy the vasculature supplying white adipose tissue. It is a chimeric peptide consisting of a targeting domain (CKGGRAKDC) that binds to prohibitin on the surface of adipose blood vessel endothelial cells, linked to a proapoptotic domain (D(KLAKLAK)₂) that disrupts mitochondrial membranes upon internalisation.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eThe targeting sequence CKGGRAKDC homes specifically to prohibitin expressed on the luminal surface of blood vessels within white adipose tissue. Upon binding, the proapoptotic KLAKLAK₂ domain is internalised and disrupts mitochondrial membranes, triggering apoptosis in the targeted endothelial cells. This leads to localised vascular regression and subsequent apoptosis of the dependent adipocytes, resulting in fat mass reduction in research models without systemic toxicity at studied doses.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTargeted adipose tissue ablation studies\u003c\/li\u003e\n\u003cli\u003eProhibitin receptor biology and vascular targeting research\u003c\/li\u003e\n\u003cli\u003eObesity and body composition modelling\u003c\/li\u003e\n\u003cli\u003eProapoptotic peptide mechanism studies\u003c\/li\u003e\n\u003cli\u003eTumour vasculature targeting research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₁₁H₂₀₆N₃₆O₂₈S₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e\n\u003cspan class=\"T286Pc\" data-sfc-cp=\"\" data-sfc-root=\"ep\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003e2557.21 g\/mol\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c!--TgQPHd||[]--\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 859216-15-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103426089224,"sku":"FTTP-2MG","price":24.9,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103426121992,"sku":"FTTP-5MG","price":49.99,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103426154760,"sku":"FTTP-10MG","price":88.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/adipotide-fttp_32a31042-6220-4535-b3a0-bc495e72e561.png?v=1782822688","url":"https:\/\/vantalabsuk.com\/products\/adipotide-fttp","provider":"Vanta Labs","version":"1.0","type":"link"}