{"title":"Muscle Growth \u0026 Performance","description":"\u003cp\u003eGrowth hormone secretagogues, IGF-1 analogues, and growth factors studied for anabolic signalling, muscle hypertrophy, and body composition research.\u003c\/p\u003e","products":[{"product_id":"cjc-1295-no-dac","title":"CJC-1295 (No DAC)","description":"\u003ch2\u003eCJC-1295 (No DAC)\u003c\/h2\u003e\n\u003cp\u003eCJC-1295 (No DAC) is a synthetic analogue of growth hormone-releasing hormone (GHRH), engineered for enhanced stability and receptor affinity compared to the native peptide. Unlike the DAC (Drug Affinity Complex) variant, CJC-1295 without DAC has a shorter half-life, producing pulsatile growth hormone release that more closely mimics endogenous GH secretion patterns. It is widely used in preclinical research investigating the GH\/IGF-1 axis, pituitary function, and anabolic signalling.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eCJC-1295 (No DAC) binds to and activates the GHRH receptor (GHRHR) on pituitary somatotroph cells, stimulating the synthesis and pulsatile release of growth hormone. This in turn drives hepatic IGF-1 production, which mediates downstream anabolic and metabolic effects including protein synthesis, lipolysis, and cellular proliferation. The peptide incorporates amino acid substitutions that confer resistance to dipeptidyl peptidase IV (DPP-IV) cleavage, extending its activity relative to native GHRH(1-29).\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGH\/IGF-1 axis and pituitary somatotroph function studies\u003c\/li\u003e\n\u003cli\u003ePulsatile growth hormone secretion modelling\u003c\/li\u003e\n\u003cli\u003eAnabolic signalling and protein synthesis research\u003c\/li\u003e\n\u003cli\u003eBody composition and metabolic regulation investigation\u003c\/li\u003e\n\u003cli\u003eGHRH receptor pharmacology studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₅₂H₂₅₂N₄₄O₄₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 863288-34-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3367.9 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103426875656,"sku":"CJC-NODAC-2MG","price":12.95,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103426908424,"sku":"CJC-NODAC-5MG","price":25.95,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103426941192,"sku":"CJC-NODAC-10MG","price":34.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/CJC-1295_No_DAC.png?v=1783026503"},{"product_id":"cjc-1295-no-dac-ipamorelin","title":"CJC-1295 (No DAC) + Ipamorelin","description":"\u003ch2\u003eCJC-1295 (No DAC) + Ipamorelin\u003c\/h2\u003e\u003cp\u003eCJC-1295 (No DAC) + Ipamorelin is a research-grade peptide blend combining two complementary growth hormone secretagogues for preclinical investigation of the GH\/IGF-1 axis. CJC-1295 (No DAC) is a GHRH analogue that stimulates pituitary somatotrophs, while Ipamorelin is a selective ghrelin receptor (GHS-R1a) agonist that promotes GH release through a distinct, independent pathway. Together, they are studied for their synergistic effects on pulsatile GH secretion in experimental models.\u003c\/p\u003e\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\u003cp\u003eCJC-1295 (No DAC) activates the GHRH receptor on pituitary somatotrophs, stimulating GH synthesis and release. Ipamorelin acts on the ghrelin receptor (GHS-R1a) to amplify GH secretion through a separate intracellular signalling cascade involving phospholipase C and protein kinase C. The combination produces additive or synergistic GH release by engaging both receptor pathways simultaneously, while Ipamorelin's high selectivity minimises off-target effects on cortisol and prolactin secretion observed with earlier GHRPs.\u003c\/p\u003e\u003ch3\u003eResearch Applications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eSynergistic GH secretagogue pharmacology studies\u003c\/li\u003e\n\u003cli\u003eGH\/IGF-1 axis and pituitary function investigation\u003c\/li\u003e\n\u003cli\u003eGhrelin receptor (GHS-R1a) signalling research\u003c\/li\u003e\n\u003cli\u003eAnabolic and metabolic regulation modelling\u003c\/li\u003e\n\u003cli\u003eCombination peptide therapy and receptor crosstalk studies\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eComposition:\u003c\/strong\u003e CJC-1295 (No DAC) + Ipamorelin peptide blend\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e Peptide blend\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e N\/A (blend)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"10mg","offer_id":58103427006728,"sku":"CJCIPA-10MG","price":34.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/CJC-1295_Plus_IPAMORELIN.png?v=1783026439"},{"product_id":"cjc-1295-with-dac","title":"CJC-1295 (With DAC)","description":"\u003ch2\u003eCJC-1295 (With DAC)\u003c\/h2\u003e\n\u003cp\u003eCJC-1295 (With DAC) is a long-acting synthetic analogue of growth hormone-releasing hormone (GHRH), engineered with a Drug Affinity Complex (DAC) technology that enables covalent binding to serum albumin. This albumin conjugation dramatically extends the peptide's half-life to approximately 6–8 days, enabling sustained, non-pulsatile elevation of growth hormone levels in research models. It is used in preclinical studies investigating chronic GH\/IGF-1 axis stimulation and its downstream metabolic and anabolic effects.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eCJC-1295 (With DAC) binds to the GHRH receptor on pituitary somatotrophs, stimulating GH synthesis and secretion. The DAC moiety — a maleimidopropionic acid linker — reacts with the free thiol group of Cys34 on serum albumin, forming a stable covalent bond that protects the peptide from enzymatic degradation and renal clearance. This results in a prolonged GH release profile distinct from the pulsatile pattern of the No DAC variant, making it a useful tool for studying the differential effects of tonic versus pulsatile GH secretion.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eChronic GH\/IGF-1 axis stimulation and sustained anabolic signalling studies\u003c\/li\u003e\n\u003cli\u003eAlbumin-binding drug delivery and pharmacokinetic research\u003c\/li\u003e\n\u003cli\u003ePulsatile vs. tonic GH secretion comparison modelling\u003c\/li\u003e\n\u003cli\u003eBody composition, lipolysis, and metabolic regulation investigation\u003c\/li\u003e\n\u003cli\u003eGHRH receptor pharmacology and long-acting peptide studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₆₅H₂₆₉N₄₇O₄₆\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 863288-34-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3647.3 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103427039496,"sku":"CJC-DAC-2MG","price":20.9,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103427072264,"sku":"CJC-DAC-5MG","price":34.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/CJC-1295_With_DAC.png?v=1783026340"},{"product_id":"ghrp-2","title":"GHRP-2 Acetate","description":"\u003ch2\u003eGHRP-2 Acetate\u003c\/h2\u003e\u003cp\u003eGHRP-2 Acetate (Growth Hormone-Releasing Peptide-2) is a research-grade synthetic hexapeptide and potent ghrelin receptor (GHS-R1a) agonist, developed for preclinical investigation of growth hormone secretion, appetite regulation, and metabolic signalling. As a second-generation GHRP, GHRP-2 exhibits greater GH-releasing potency than GHRP-6 with a comparatively reduced orexigenic effect, making it a widely used tool compound in GH axis research and neuroendocrine pharmacology.\u003c\/p\u003e\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\u003cp\u003eGHRP-2 binds to and activates the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons, stimulating GH release through a mechanism distinct from and complementary to GHRH. It activates phospholipase C and protein kinase C signalling cascades, increasing intracellular calcium and triggering GH secretion. GHRP-2 also partially antagonises somatostatin tone, further amplifying GH pulse amplitude. Unlike GHRP-6, GHRP-2 has a lower affinity for the CD36 receptor, resulting in a reduced appetite-stimulating effect while maintaining robust GH secretagogue activity.\u003c\/p\u003e\u003ch3\u003eResearch Applications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eGH secretagogue pharmacology and pituitary function studies\u003c\/li\u003e\n\u003cli\u003eGhrelin receptor (GHS-R1a) signalling research\u003c\/li\u003e\n\u003cli\u003eGH\/IGF-1 axis and anabolic signalling investigation\u003c\/li\u003e\n\u003cli\u003eSomatostatin antagonism and GH pulse modulation\u003c\/li\u003e\n\u003cli\u003eAppetite regulation and metabolic signalling research\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₄₅H₅₅N₉O₆ · C₂H₄O₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 158861-67-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 817.9 g\/mol (acetate salt)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103427498248,"sku":"GHRP2-5MG","price":9.5,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103427531016,"sku":"GHRP2-10MG","price":13.5,"currency_code":"GBP","in_stock":true},{"title":"15mg","offer_id":58103427563784,"sku":"GHRP2-15MG","price":17.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/ghrp-2-acetate.png?v=1782940028"},{"product_id":"ghrp-6","title":"GHRP-6 Acetate","description":"\u003ch2\u003eGHRP-6 Acetate\u003c\/h2\u003e\n\u003cp\u003eGHRP-6 Acetate (Growth Hormone-Releasing Peptide-6) is a research-grade synthetic hexapeptide and first-generation ghrelin receptor (GHS-R1a) agonist, developed for preclinical investigation of growth hormone secretion, appetite regulation, and gastric motility. As the prototypical GHRP, GHRP-6 has been extensively characterised in experimental models and remains a key reference compound in GH secretagogue pharmacology, particularly for studies examining the orexigenic and GH-releasing properties of ghrelin receptor activation.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eGHRP-6 binds to the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons, stimulating GH release through phospholipase C and protein kinase C signalling cascades. It also binds to the CD36 scavenger receptor, which mediates its pronounced appetite-stimulating (orexigenic) effect — a distinguishing feature compared to later-generation GHRPs. GHRP-6 partially antagonises somatostatin tone and acts synergistically with GHRH to amplify GH pulse amplitude, making it a useful tool for studying the interplay between these two regulatory axes.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGH secretagogue pharmacology and pituitary function studies\u003c\/li\u003e\n\u003cli\u003eGhrelin receptor (GHS-R1a) and CD36 receptor signalling research\u003c\/li\u003e\n\u003cli\u003eAppetite regulation and orexigenic pathway investigation\u003c\/li\u003e\n\u003cli\u003eGH\/IGF-1 axis and anabolic signalling modelling\u003c\/li\u003e\n\u003cli\u003eGastric motility and gastrointestinal function studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₄₆H₅₆N₁₀O₆ · C₂H₄O₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e145177-42-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e1053.20 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103427596552,"sku":"GHRP6-5MG","price":14.5,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103427629320,"sku":"GHRP6-10MG","price":22.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/ghrp-6-acetate.png?v=1782940115"},{"product_id":"hexarelin","title":"Hexarelin Acetate","description":"\u003ch2\u003eHexarelin Acetate\u003c\/h2\u003e\n\u003cp\u003eHexarelin Acetate is a research-grade synthetic hexapeptide and potent ghrelin receptor (GHS-R1a) agonist, developed for preclinical investigation of growth hormone secretion, cardiac function, and neuroendocrine signalling. As one of the most potent GHRPs characterised to date, Hexarelin exhibits a high binding affinity for GHS-R1a and has been studied extensively in experimental models of GH axis regulation, cardioprotection, and hypothalamic-pituitary function.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eHexarelin binds with high affinity to the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons, activating phospholipase C and protein kinase C signalling cascades to stimulate robust GH secretion. It also partially antagonises somatostatin tone, amplifying GH pulse amplitude. Notably, Hexarelin has been shown to bind to CD36 and the growth hormone secretagogue receptor type 1b (GHS-R1b), and preclinical studies have demonstrated direct cardioprotective effects independent of GH release, including attenuation of ischaemia-reperfusion injury and modulation of cardiac contractility via CD36-mediated signalling.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGH secretagogue pharmacology and pituitary function studies\u003c\/li\u003e\n\u003cli\u003eGhrelin receptor (GHS-R1a) signalling and binding affinity research\u003c\/li\u003e\n\u003cli\u003eCardioprotection and ischaemia-reperfusion injury modelling\u003c\/li\u003e\n\u003cli\u003eCD36 receptor signalling and cardiac function investigation\u003c\/li\u003e\n\u003cli\u003eGH\/IGF-1 axis and anabolic signalling studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₄₇H₅₈N₁₂O₆\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 140703-51-1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 887.0 g\/mol (acetate salt)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103428055304,"sku":"HEXAR-2MG","price":12.0,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103428088072,"sku":"HEXAR-5MG","price":26.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/hexarelin-acetate.png?v=1782941304"},{"product_id":"hgh","title":"HGH","description":"\u003ch2\u003eHGH (Human Growth Hormone \/ Somatropin)\u003c\/h2\u003e\n\u003cp\u003eHGH (Human Growth Hormone, Somatropin) is a research-grade recombinant 191-amino acid polypeptide hormone identical in sequence to endogenous pituitary-derived growth hormone, developed for preclinical investigation of the GH\/IGF-1 axis, anabolic signalling, metabolic regulation, and tissue growth. As the primary mediator of somatic growth and a key regulator of protein, lipid, and carbohydrate metabolism, recombinant HGH is a foundational tool compound in endocrinology, metabolic disease research, and regenerative biology.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eHGH binds to the growth hormone receptor (GHR), a class I cytokine receptor, inducing receptor dimerisation and activation of the JAK2\/STAT5 signalling pathway. This drives the hepatic and peripheral production of insulin-like growth factor 1 (IGF-1), which mediates many of GH's anabolic and mitogenic effects including protein synthesis, cell proliferation, and longitudinal bone growth. GH also exerts direct metabolic effects independent of IGF-1, including lipolysis stimulation, insulin antagonism, and glucose homeostasis modulation. In preclinical models, GH has been studied for its roles in muscle hypertrophy, adipose tissue regulation, immune function, and wound healing.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGH\/IGF-1 axis regulation and somatotroph biology studies\u003c\/li\u003e\n\u003cli\u003eJAK2\/STAT5 signalling and cytokine receptor pharmacology research\u003c\/li\u003e\n\u003cli\u003eAnabolic signalling, protein synthesis, and muscle biology investigation\u003c\/li\u003e\n\u003cli\u003eMetabolic regulation, lipolysis, and glucose homeostasis modelling\u003c\/li\u003e\n\u003cli\u003eLongitudinal bone growth and chondrocyte biology studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₉₉₀H₁₅₂₈N₂₆₂O₃₀₀S₇\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 12629-01-5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 22,124 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"10 IU","offer_id":58103428120840,"sku":"HGH-10IU","price":38.5,"currency_code":"GBP","in_stock":true},{"title":"15 IU","offer_id":58103428153608,"sku":"HGH-15IU","price":50.0,"currency_code":"GBP","in_stock":true},{"title":"20 IU","offer_id":58103428186376,"sku":"HGH-20IU","price":84.99,"currency_code":"GBP","in_stock":true},{"title":"24 IU","offer_id":58103428219144,"sku":"HGH-24IU","price":98.5,"currency_code":"GBP","in_stock":true},{"title":"36 IU","offer_id":58103428251912,"sku":"HGH-36IU","price":138.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/hgh.png?v=1782941482"},{"product_id":"hgh-fragment","title":"HGH Fragment 176-191","description":"\u003ch2\u003eHGH Fragment 176-191\u003c\/h2\u003e\n\u003cp\u003eHGH Fragment 176-191 is a synthetic peptide corresponding to amino acids 176–191 of the C-terminal region of human growth hormone (hGH), a 16-amino acid sequence that encompasses the lipolytic domain of the GH molecule. It was developed by researchers at Monash University as part of a programme to isolate the fat-metabolising activity of GH from its growth-promoting and diabetogenic effects. HGH Fragment 176-191 retains the lipolytic potency of full-length GH while lacking significant activity at the GH receptor (GHR) for IGF-1 stimulation or insulin resistance induction, making it a selective research tool for studying GH-mediated lipolysis and adipose tissue metabolism.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eHGH Fragment 176-191 exerts its lipolytic effects through a mechanism that is distinct from classical GHR-mediated signalling. Unlike full-length GH, which activates the GHR\/JAK2\/STAT5 pathway to stimulate IGF-1 production and promote growth, HGH Fragment 176-191 does not bind the GHR with significant affinity and does not stimulate IGF-1 secretion. Instead, it is proposed to act via a β-adrenergic-like mechanism, stimulating adenylyl cyclase and cAMP production in adipocytes, which activates hormone-sensitive lipase (HSL) and promotes triglyceride hydrolysis and fatty acid release. It also inhibits lipogenesis by reducing the activity of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), providing a dual mechanism of lipolysis stimulation and lipogenesis inhibition in adipose tissue research models.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGH lipolytic domain pharmacology and adipocyte lipolysis mechanism studies\u003c\/li\u003e\n\u003cli\u003eHormone-sensitive lipase (HSL) activation and triglyceride hydrolysis research\u003c\/li\u003e\n\u003cli\u003eLipogenesis inhibition, fatty acid synthase (FAS), and ACC regulation investigation\u003c\/li\u003e\n\u003cli\u003eAdipose tissue metabolism, body composition, and fat mobilisation preclinical models\u003c\/li\u003e\n\u003cli\u003eGH fragment biology and structure-activity relationship (SAR) research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₇₈H₁₂₃N₂₃O₂₂S₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1817.1 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e\n\u003cspan class=\"T286Pc\" data-sfc-cp=\"\" data-sfc-root=\"ep\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Arial, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(230, 232, 240);'\u003e 66004-57-7\u003c!--TgQPHd||[]--\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103428284680,"sku":"HGHFRAG-2MG","price":22.5,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103428317448,"sku":"HGHFRAG-5MG","price":35.9,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103428350216,"sku":"HGHFRAG-10MG","price":62.5,"currency_code":"GBP","in_stock":true},{"title":"12mg","offer_id":58103428382984,"sku":"HGHFRAG-12MG","price":81.5,"currency_code":"GBP","in_stock":true},{"title":"15mg","offer_id":58103428415752,"sku":"HGHFRAG-15MG","price":99.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/hgh-fragment-176-191.png?v=1782932332"},{"product_id":"igf-1-lr3","title":"IGF-1 LR3","description":"\u003ch2\u003eIGF-1 LR3 (Long R3 IGF-1)\u003c\/h2\u003e\n\u003cp\u003eIGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic recombinant analogue of human IGF-1 incorporating two structural modifications: an N-terminal methionine extension (the “Long” designation) and a glutamic acid-to-arginine substitution at position 3 (the “R3” designation). These modifications were designed to dramatically reduce binding affinity for IGF-binding proteins (IGFBPs) while maintaining full potency at the IGF-1 receptor (IGF-1R). IGF-1 LR3 has approximately 2–3 times the potency of native IGF-1 at IGF-1R and a significantly extended half-life in biological systems due to its reduced IGFBP sequestration, making it one of the most widely used research tools for studying IGF-1R-mediated anabolic and proliferative signalling.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eIGF-1 LR3 acts as a potent full agonist of the IGF-1 receptor (IGF-1R), a heterotetrameric receptor tyrosine kinase. Ligand binding induces receptor autophosphorylation and activation of the insulin receptor substrate (IRS) proteins, initiating downstream signalling through the PI3K\/Akt\/mTOR pathway (mediating protein synthesis, glucose uptake, and anti-apoptotic effects) and the Ras\/MAPK\/ERK pathway (mediating cell proliferation and differentiation). The Arg3 substitution reduces affinity for IGFBP-1, -2, -3, -4, -5, and -6 by approximately 1000-fold compared to native IGF-1, while the N-terminal extension further reduces IGFBP-3 binding. This results in a molecule that is predominantly in the free, bioactive form in biological systems, providing sustained IGF-1R activation that is not attenuated by endogenous IGFBP sequestration.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eIGF-1R pharmacology, receptor tyrosine kinase signalling, and IRS pathway studies\u003c\/li\u003e\n\u003cli\u003ePI3K\/Akt\/mTOR and MAPK\/ERK anabolic signalling research\u003c\/li\u003e\n\u003cli\u003eIGFBP-independent IGF-1 signalling and extended half-life investigation\u003c\/li\u003e\n\u003cli\u003eMuscle hypertrophy, satellite cell biology, and skeletal muscle anabolism research\u003c\/li\u003e\n\u003cli\u003eCell proliferation, differentiation, and anti-apoptotic signalling preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 9117.5 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 946870-92-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"0.1mg","offer_id":58103428579592,"sku":"IGF1LR3-01MG","price":20.95,"currency_code":"GBP","in_stock":true},{"title":"1mg","offer_id":58103428612360,"sku":"IGF1LR3-1MG","price":39.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/igf-1-lr3.png?v=1782922275"},{"product_id":"igf-des","title":"IGF-DES","description":"\u003ch2\u003eIGF-DES (Des(1-3)IGF-1)\u003c\/h2\u003e\u003cp\u003eIGF-DES, formally designated Des(1-3)IGF-1, is a naturally occurring truncated isoform of insulin-like growth factor 1 (IGF-1) in which the first three N-terminal amino acids (Gly-Pro-Glu) have been removed. This truncation is generated in vivo by specific proteolytic cleavage in the brain and other tissues, and results in a molecule with markedly altered binding properties compared to full-length IGF-1. IGF-DES has approximately 10-fold lower affinity for IGF-binding proteins (IGFBPs) than full-length IGF-1, while retaining full potency at the IGF-1 receptor (IGF-1R), making it a highly bioavailable and potent research tool for studying IGF-1R-mediated signalling in the absence of IGFBP-mediated sequestration.\u003c\/p\u003e\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\u003cp\u003eIGF-DES acts as a full agonist of the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase that activates the PI3K\/Akt\/mTOR and Ras\/MAPK\/ERK signalling cascades upon ligand binding. These pathways mediate the anabolic, anti-apoptotic, and proliferative effects of IGF-1 signalling in muscle, bone, neural, and other tissues. The critical distinction of IGF-DES from full-length IGF-1 is its dramatically reduced affinity for IGFBPs (particularly IGFBP-3), which normally sequester the majority of circulating IGF-1 and limit its bioavailability. By bypassing IGFBP binding, IGF-DES provides a research tool for studying IGF-1R activation in a context that more closely approximates free, unbound IGF-1 activity, and is particularly useful for investigating local tissue IGF-1 signalling independent of systemic IGFBP regulation.\u003c\/p\u003e\u003ch3\u003eResearch Applications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eIGF-1R pharmacology and receptor tyrosine kinase signalling studies\u003c\/li\u003e\n\u003cli\u003ePI3K\/Akt\/mTOR and MAPK\/ERK pathway activation research\u003c\/li\u003e\n\u003cli\u003eIGFBP-independent IGF-1 signalling and bioavailability investigation\u003c\/li\u003e\n\u003cli\u003eMuscle hypertrophy, satellite cell activation, and anabolic signalling research\u003c\/li\u003e\n\u003cli\u003eNeuroprotection, neurogenesis, and CNS IGF-1R function preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e Truncated IGF-1 analogue (Des(1-3)IGF-1)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 7371.4 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 112603-35-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103428645128,"sku":"IGFDES-2MG","price":50.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/igf-des.png?v=1782921946"},{"product_id":"ipamorelin","title":"Ipamorelin","description":"\u003ch2\u003eIpamorelin\u003c\/h2\u003e\n\u003cp\u003eIpamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) and selective ghrelin receptor agonist, developed by Novo Nordisk as part of a programme to identify GHS compounds with improved selectivity profiles. It is structurally related to GHRP-1 and GHRP-2 but is distinguished by its high selectivity for the GH secretagogue receptor (GHSR-1a) with minimal off-target activity at cortisol, prolactin, or ACTH release pathways — a key pharmacological advantage that makes it a cleaner research tool for studying GH axis stimulation compared to earlier GHRPs. Ipamorelin has been extensively studied in preclinical research for its effects on GH and IGF-1 secretion, body composition, bone density, and gastrointestinal motility.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eIpamorelin acts as a potent, selective agonist of GHSR-1a, the ghrelin receptor expressed in the hypothalamus, pituitary somatotrophs, and peripheral tissues. GHSR-1a activation stimulates pulsatile GH release from pituitary somatotrophs via Gq\/11-mediated phospholipase C activation and intracellular calcium mobilisation, as well as Gi-mediated cAMP modulation. Unlike GHRP-2 and GHRP-6, Ipamorelin does not significantly stimulate cortisol or ACTH release at GH-stimulating doses, and has minimal effect on prolactin secretion, reflecting its high receptor selectivity. The resulting GH pulses drive hepatic IGF-1 production, mediating downstream anabolic, lipolytic, and tissue-remodelling effects. Ipamorelin also acts synergistically with GHRH analogues (such as CJC-1295 or Sermorelin), as the two pathways converge on somatotroph GH release through complementary mechanisms.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGHSR-1a pharmacology and selective GHS receptor agonism studies\u003c\/li\u003e\n\u003cli\u003eGH and IGF-1 axis stimulation and somatotropic signalling research\u003c\/li\u003e\n\u003cli\u003eBody composition, lean mass, and adipose tissue metabolism investigation\u003c\/li\u003e\n\u003cli\u003eBone mineral density and skeletal remodelling preclinical models\u003c\/li\u003e\n\u003cli\u003eGastrointestinal motility and GHS receptor peripheral function research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₃₈H₄₉N₉O₅\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 711.9 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 170851-70-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103428677896,"sku":"IPA-5MG","price":19.95,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103428710664,"sku":"IPA-10MG","price":29.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/ipamorelin.png?v=1782921427"},{"product_id":"mk-677","title":"MK-677","description":"\u003ch2\u003eMK-677 (Ibutamoren)\u003c\/h2\u003e\n\u003cp\u003eMK-677, also known as Ibutamoren or MK-0677, is a synthetic non-peptide ghrelin receptor agonist and growth hormone secretagogue (GHS) developed by Merck \u0026amp; Co. Unlike peptide-based GHS compounds, MK-677 is orally bioavailable and has a prolonged half-life of approximately 24 hours, making it a practical research tool for sustained GH axis stimulation. It has been extensively studied in preclinical and clinical research for its effects on GH and IGF-1 secretion, body composition, bone density, sleep architecture, and metabolic regulation.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMK-677 acts as a potent, selective agonist of the ghrelin receptor (GHSR-1a), a G-protein-coupled receptor expressed in the hypothalamus and pituitary. GHSR-1a activation stimulates pulsatile GH release from pituitary somatotrophs via a mechanism that is additive with endogenous GHRH signalling and partially independent of somatostatin inhibition. The resulting GH pulses drive hepatic IGF-1 production, which mediates downstream anabolic, lipolytic, and tissue-remodelling effects. MK-677 also activates hypothalamic neuropeptide Y (NPY) pathways, stimulating appetite — a characteristic feature of ghrelin receptor agonism that is of research interest in cachexia and metabolic disease models.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGhrelin receptor (GHSR-1a) pharmacology and GH secretagogue studies\u003c\/li\u003e\n\u003cli\u003eGH and IGF-1 axis stimulation and somatotropic signalling research\u003c\/li\u003e\n\u003cli\u003eBody composition, lean mass, and adipose tissue metabolism investigation\u003c\/li\u003e\n\u003cli\u003eBone mineral density and skeletal remodelling preclinical models\u003c\/li\u003e\n\u003cli\u003eSleep architecture, REM sleep, and slow-wave sleep research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₂₇H₃₆N₄O₅S • CH₄O₃S\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 624.8 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 159752-10-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"5mg","offer_id":58103429759240,"sku":"MK677-5MG","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/mk-677.png?v=1782914781"},{"product_id":"peg-mgf","title":"PEG MGF","description":"\u003ch2\u003ePEG MGF (PEGylated Mechano Growth Factor)\u003c\/h2\u003e\n\u003cp\u003ePEG MGF is a PEGylated synthetic analogue of Mechano Growth Factor (MGF), a splice variant of the IGF-1 gene that is expressed in response to mechanical loading and tissue damage. The polyethylene glycol (PEG) modification significantly extends the plasma half-life of the native MGF peptide from minutes to several days, enabling sustained receptor engagement and making it a more practical tool for preclinical research. PEG MGF has been studied in preclinical models for its roles in muscle satellite cell activation, tissue repair, and anabolic signalling, distinct from the systemic IGF-1 pathway.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eMGF is generated by alternative splicing of the IGF-1 gene following mechanical stress or tissue injury, and signals through a distinct receptor pathway from mature IGF-1. The MGF E-domain peptide activates muscle satellite cells (myogenic stem cells), promoting their proliferation and differentiation into new myofibres — a process critical for muscle repair and hypertrophy. PEGylation of the MGF peptide prevents rapid enzymatic degradation, extending its biological activity and enabling investigation of sustained MGF receptor signalling in vitro and in preclinical models. PEG MGF does not bind the IGF-1 receptor with the same affinity as mature IGF-1, making it a selective tool for studying the MGF-specific signalling axis.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eMuscle satellite cell activation, proliferation, and myogenic differentiation studies\u003c\/li\u003e\n\u003cli\u003eMechano-sensitive IGF-1 splice variant signalling research\u003c\/li\u003e\n\u003cli\u003eSkeletal muscle repair and regeneration preclinical models\u003c\/li\u003e\n\u003cli\u003eAnabolic signalling and muscle hypertrophy investigation\u003c\/li\u003e\n\u003cli\u003ePEGylation pharmacokinetics and half-life extension research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₂₁H₂₀₀N₄₂O₃₉\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e2867.20 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e108174-48-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103430447368,"sku":"PEGMGF-2MG","price":19.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/peg-mgf.png?v=1782896345"},{"product_id":"sermorelin","title":"Sermorelin Acetate","description":"\u003ch2\u003eSermorelin Acetate\u003c\/h2\u003e\n\u003cp\u003eSermorelin Acetate is a synthetic peptide corresponding to the biologically active N-terminal 29-amino acid fragment of endogenous growth hormone-releasing hormone (GHRH 1-29 NH2). It is the shortest GHRH fragment known to retain full biological activity at the GHRH receptor, making it a well-characterised and widely used research tool for studying the somatotropic axis. Sermorelin has been extensively investigated in preclinical and clinical research contexts for its capacity to stimulate pulsatile growth hormone secretion from the anterior pituitary.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eSermorelin binds to and activates the GHRH receptor (GHRHR) on pituitary somatotroph cells, stimulating the synthesis and pulsatile release of endogenous growth hormone (GH) via a cAMP-dependent signalling cascade. The resulting GH elevation promotes hepatic IGF-1 production, which mediates downstream anabolic, lipolytic, and tissue-remodelling effects. Unlike exogenous GH administration, sermorelin preserves the physiological feedback regulation of the hypothalamic-pituitary-somatotropic axis, including somatostatin-mediated inhibition, making it a valuable tool for studying GHRH receptor pharmacology and GH secretion dynamics.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGHRH receptor pharmacology and pituitary somatotroph function studies\u003c\/li\u003e\n\u003cli\u003eGrowth hormone secretion, pulsatility, and feedback regulation research\u003c\/li\u003e\n\u003cli\u003eIGF-1 axis dynamics and downstream anabolic signalling investigation\u003c\/li\u003e\n\u003cli\u003eAge-related GH decline and somatopause modelling\u003c\/li\u003e\n\u003cli\u003eBody composition, lipolysis, and metabolic regulation research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₁₄₉H₂₄₆N₄₄O₄₂S\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3357.9 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 86168-78-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103431299336,"sku":"SERM-2MG","price":12.9,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103431332104,"sku":"SERM-5MG","price":29.0,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103431364872,"sku":"SERM-10MG","price":49.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/sermorelin-acetate.png?v=1782894994"},{"product_id":"tesamorelin","title":"Tesamorelin","description":"\u003ch2\u003eTesamorelin\u003c\/h2\u003e\n\u003cp\u003eTesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH), comprising the full 44-amino acid sequence of endogenous GHRH with a trans-3-hexenoic acid modification at the N-terminus to enhance stability. It is a well-characterised GHRH receptor agonist that has been extensively studied in the context of growth hormone secretion, body composition, and metabolic regulation. Tesamorelin is supplied here as a lyophilised research compound for in vitro and preclinical investigation.\u003c\/p\u003e\n\u003ch3\u003eMechanism of Action\u003c\/h3\u003e\n\u003cp\u003eTesamorelin binds to and activates the GHRH receptor (GHRHR) on somatotroph cells of the anterior pituitary, stimulating the pulsatile release of endogenous growth hormone (GH). The resulting GH elevation promotes hepatic IGF-1 synthesis, which mediates downstream anabolic and lipolytic effects. Unlike exogenous GH administration, tesamorelin preserves the physiological pulsatility of GH secretion and operates within the feedback regulation of the somatotropic axis, making it a valuable tool for studying GHRH receptor pharmacology and GH-IGF-1 axis dynamics.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eGHRH receptor pharmacology and pituitary somatotroph function studies\u003c\/li\u003e\n\u003cli\u003eGrowth hormone secretion and pulsatility modelling\u003c\/li\u003e\n\u003cli\u003eIGF-1 axis regulation and downstream signalling research\u003c\/li\u003e\n\u003cli\u003eVisceral adipose tissue metabolism and lipolysis investigation\u003c\/li\u003e\n\u003cli\u003eBody composition and metabolic syndrome preclinical models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eC₂₂₁H₃₆₆N₇₂O₆₇S\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003e5135.89 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 218949-48-5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf Life:\u003c\/strong\u003e 24 months\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product is intended for legitimate laboratory and analytical research use only. Not for diagnostic, therapeutic, or consumer use.\u003c\/em\u003e\u003c\/p\u003e","brand":"Vanta Labs","offers":[{"title":"2mg","offer_id":58103431856392,"sku":"TESA-2MG","price":27.9,"currency_code":"GBP","in_stock":true},{"title":"5mg","offer_id":58103431889160,"sku":"TESA-5MG","price":27.9,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":58103431921928,"sku":"TESA-10MG","price":50.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1049\/8886\/8872\/files\/tesamorelin.png?v=1782893484"}],"url":"https:\/\/vantalabsuk.com\/collections\/muscle-growth-performance.oembed","provider":"Vanta Labs","version":"1.0","type":"link"}